TTP and Atlas Genetics created a point-of-care instrument for the diagnosis of infectious disease.
Working with Atlas Genetics, we developed the io Reader® which operates a test-specific cartridge that fully automates a three-stage process of DNA extraction and purification, amplification, and electrochemical detection - traditionally a complex laboratory process.
The operator simply adds a sample to the cartridge, inserts it into the reader, and follows the on-screen instructions.
We achieved a small instrument footprint, important to many laboratories, by using an effective, pneumatic, economic and mechanical architecture.
We chose TTP on the basis of ‘lowest risk/highest reward’. In particular I was impressed with the combination of TTP’s technical capabilities, structured approach and project management skills. The project was a great success because it had the right amount of innovation and practical engineering solutions; and all of the software development work went through the production and verification steps smoothly and on time (notable because project overruns frequently occur due to software failures). The first production units were delivered within the tight 12-month timeframe required at the end of 2013. This ensured that Atlas was on track with the timetable it had promised.
- Achieving multiple interfaces (force, pneumatic, thermal, electronic) between instrument and cartridge.
- Effecting a short, accurate and repeatable PCR temperature cycle.
- Realising form factor acceptable to healthcare professionals.
- Hitting tough cost targets.