TTP has been exceptional to work with. They are sharp and experienced and were able to quickly adapt to changing business needs. They are clearly expert at what they do, which made our job easier. We felt we could trust them to do the job right and communicate results clearly. They were also fun to work with, having laid-back styles and engaging personalities. I’d highly recommend TTP and will definitely use them in the future if the need arises!
Industries
Neurotechnology
Whether you are looking for de novo device development, are making the jump from your first proof-of-concept to a production-ready design, or need to troubleshoot specific aspects of your system, we create bespoke technology solutions for implantable medical devices.
Inventing the future of neurotechnology
We invent and innovate with our clients. Whether you are looking for de novo device development, are making the jump from your first proof-of-concept to a production-ready design, or need to troubleshoot specific aspects of your system, TTP creates bespoke technology solutions for implantable medical devices.
We pride ourselves on our flexibility to adapt to your needs and integrate with your design team in order to accelerate your time to market.
Delivering novel neuromodulation therapies requires a truly multi-disciplinary team, with expertise in implantable medical device development, multi-physics modelling, advanced electronics and RF design, low-power sensing, and embedded processing techniques. These capabilities are enabling the next generation of neurotechnology devices to deliver novel, personalised therapies and achieve better outcomes for patients.
Why TTP
IPG development
Implantable Pulse Generators (IPG) are moving towards greater functionality and smaller size. Innovation requires low-power electronics expertise and custom power and comms solutions, all tightly integrated into a biocompatible hermetic package. TTP has the multi-disciplinary capabilities to help develop the next generation of IPGs.
Custom antenna design for power and communications
Leveraging the smartphone interface to enable condition monitoring and control of neuromodulation parameters can increase patient engagement, allow therapy personalisation, and result in improved outcomes. This requires the implementation of custom data links and comms protocols, and the application of machine learning to this data can then generate insights to maximise treatment efficacy.
Nerve sensing for closed-loop therapies
Neuromodulation systems that can modify or titrate therapies in response to nerve behaviour have been shown to deliver more effective therapies. Sensing and extracting actionable features from nerve signals requires the development of highly sensitive electrodes and the use of efficient signal processing techniques. Closing this loop will enable real-time adaptive therapies for maximum patient impact.
Director of New Therapies Marketing & Neuroscience, Medtronic
Expertise
IPG development
Developing custom electronics, caseworks, feedthroughs and seals to create application-specific implantable devices in the smallest form factor.
Low-power electronics
Designing tightly integrated electronics to optimise power efficiency for maximum device life.
Wireless power & communications
Producing tailored power and data transfer links, and integrating standard protocols such as BLE to enable greater user engagement.
Closed-loop stimulation
Incorporating real-time sensing and feature recognition algorithms to enable automated stimulation activation and titration.
Understanding through simulation
Starting from a first-principles understanding of a challenge to quickly optimise solutions, and de-risk early in the development process.
Human factors
Ensuring that the device that is developed is intuitive to use, and fit for purpose for the users, clinicians, and surgeons that install it.
Manufacturing scale-up
Considering manufacturability from the start of development, making the transition from first proof-of-concept to controlled GMP device manufacture a smooth process.
Cost reduction
Engineering solutions to meet tight cost requirements, improve margins, grow market share, or allow access to new markets with more affordable products.
Digital health
Applying data analytics to generate patient and treatment insights, enabling personalised therapies that maximise treatment efficacy for patients.
News & Insights
Invent: Health – Epilepsy: the brain when disorders occur
In the second episode of Invent:Health Season 2, Matt Parker speaks to Alex Stokoe, a neurotechnology consultant at TTP, and Professor Martha Morrell, Clinical Professor of Neurology at Stanford University
TTP integrates optical design for intra-cranial pressure monitor
Third Eye Diagnostics wanted to measure the pressure inside the skull with a device that uses the eye as a window to the brain. Doing so could have huge benefits for patients.
Hannah Claridge on the Neural Implant Podcast
Hannah Claridge, Head of Neurotechnology, speaks to Ladan Jiracek on the Neural Implant Podcast on all things neurotechnology and consulting.
Hear from Hannah on the process behind neuromodulation device development, what an average day looks like, and how to follow a career in technology consulting.
Invent: Health – Pain: How to feel less pain
On a scale of 1 to 10, how much does it hurt? How many times have you heard that from a doctor? With all the imaging technology, implants, and next-generation medical devices available today, asking someone in today’s world to rate their own pain sensation on a scale of 1 to 10 feels almost backward.
Hannah Claridge, Head of Neurotechnology, speaks to Matt Millington on the topic of pain and debates the question; Are we nearing the end of feeling pain?
Will passive implantables be the next frontier in biosensing?
Technology developments have given us increasingly powerful and portable biosensors that can fit seamlessly into our lives – for example, glucose monitoring for diabetics. Consumer trends show there is further appetite for new technologies that provide accurate, reliable, affordable, discrete, and truly long-term biosensing.
Personalising neurostimulation in chronic pain management
Nerve stimulation therapies for chronic pain can be very successful. But patients and clinicians face day-to-day challenges in the delivery of therapy that call for greater personalisation. Adaptive stimulation paradigms based on neural sensing data could help to achieve this – and give us additional insights.
Kernel: Light speed towards accessible brain imaging
Alex Stokoe and Alon Greenenko in our neurotech team take a look into what Kernel, one of the world’s hottest neurotech start-ups is up to. Get the inside scoop as they sit down with Ryan Field, the CTO.
Is ultrasound the key to powering the next generation of implants?
Ultrasound can be used to charge and power even the smallest implants that are out of reach for inductive power transmission methods. How will we be able to take full advantage of ultrasound to power future implants?
Designing the next generation of implantable neurostimulators
Delivering a market-leading IPG with the smallest volume requires a multi-disciplinary approach that creatively considers functionality and manufacturability across multiple domains.
C3Bio: Implementing real-time vagus nerve recording
Reading the signs of migraines with ML: from algorithm to successful product development
Some very common medical conditions like migraine have evaded diagnosis and treatment until now. We explore why Machine Learning might finally be the tool to tame migraines but why it is still not an easy path to a successful product.
Alzheimer’s and Parkinson’s Disease: are we looking in the wrong places?
Over the last decade, the brain has been the focal point for the origin of these diseases, but scientists are now turning their attention to elsewhere in the body for possible trigger sites and thus targets for novel therapies. Does the gut and its diverse microbiota hold any clues?
Smart implants: surgical nail for monitoring bone healing
Smart, sensor-bearing implants can help doctors track healing and patient progress after they have left hospital. And, unlike external braces, the twin utilities of a smart implant – structural support and monitoring – are not affected by variable patient compliance. Smart implants can thus be a key tool for delivering treatment with less pressure on our healthcare systems.
Invent: Health – Neurotech: How to speak to the brain
Imagine brain implants that could treat Alzheimer’s, epilepsy, manage diabetes, moderate our appetite, and even our mental health. Imagine brain-machine interfaces that could enable us to control machines through thought. This is not far-off science fiction, this is today.
In this Invent episode, members from the Neurotechnology team at TTP talk to Matt Millington on the topic of Neurotechnology and how the field has been progressing with technologies previously seen as sci-fi.
