Front-loading monoclonal antibody screening for faster drug discovery
Monoclonal antibodies offer promise in the fight against a wide range of diseases, including COVID-19. The length of the discovery process is a barrier to emergency use, however, and poses a commercial risk for pharmaceutical companies. Multidisciplinary innovation could step up the pace, says Verity Jackson.
Remote user testing for medical device development: advantages as well as challenges abound
Remote user testing allowed us to substantially accelerate the development of the CoVent™ ventilator. Dan Lock reviews the impact of social distancing on user research and finds that many of our necessary adaptations will continue to have value. Yet, each new study challenges us to come up with new approaches to inform medical device development.
Autonomous mobility: How do we prevent vehicles from going blind?
To deliver on the promise of greater safety than human drivers, the sensors of autonomous vehicles need to be kept spotlessly clean. Which technology is up to the task, and who will take ownership of what could become a point of competitive advantage in a burgeoning industry, asks Tom Jellicoe.
What failure rate are we willing to accept in cell therapy manufacture? Insights from medical device development
Autologous cell therapies hold great promise in the treatment of many cancers but are generally produced using processes and equipment for which there are concerns as to whether they are sufficiently reliable to support scale-out to 1000s of systems. Medical device development holds important lessons for achieving the required reliability for cell therapy automation equipment.
5G NGSO Broadband Failures – What Next for Investors?
After the LeoSat and OneWeb bankruptcies and Intelsat’s Chapter 11 filing, what’s next for satcom investors? Will the 5G IoT opportunity come into sharper focus? Adrian Hillier and Peter Kibutu revisit their triangle of competitive differentiation in the satcom industry.
Biomimetics evolution at the micron scale and beyond
From Velcro to human flight, biomimicry has inspired the development of products and industries. During the 2020s, microfabrication and other bottom-up approaches will likely lead to many more bio-inspired ideas achieving technical and commercial success, says Fred Hussain.
Sustainable innovation: business model and technology must evolve together
Most companies are already setting themselves specific sustainability targets. The question now is how to meet them. Sam Hair and Michael Sequeira show how business model and technology innovation should work in tandem to achieve improved sustainability success.
Special Delivery: can advanced intracellular delivery enable superior cell therapies for solid tumour treatment – and beyond?
Inspired by the promise of CAR-T cell therapy, new technologies to combat the hostile solid tumour microenvironment are being developed, underpinned by innovations in intracellular delivery, say Megan McCandless and Stuart Lowe.
Only a ‘click’ away: click chemistry transforms life science applications
Click chemistry has come into its own in a wide range of life science applications and opens up opportunities that lie between chemistry, biology and material science, says Wenshu Xu.
Accelerating medical device development: Lessons from CoVent and the UK ventilator challenge
Developing a medical device in weeks rather than years during the coronavirus pandemic was an extraordinary undertaking. Dan Strange reviews TTP’s “Project Jarre” to develop the CoVent(TM) ventilator and draws some lessons as to how – when needs must – faster medical device development is possible.