Cell and Gene Therapy

Cell and Gene Therapies can cure the incurable. With more than a decade of experience, TTP works in partnership with companies to solve the challenges of these complex therapies. Together we will improve patient access and save lives.

Cell Gene Update
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With an increasing number of cell and gene therapies available or in clinical trials, these novel treatments have been proven to successfully treat disease. However, the ability to commercialise these products presents major challenges.

Traditional scale-up of manufacture is not possible for autologous cell therapies, since these treatments use a patient’s own cells they are therefore personalised and patient-specific. Similarly, allogenic cell therapy production is limited because the cell itself is the therapeutic agent, and biomanufacture challenges cell integrity, functionality, and can lead to inhomogeneity. 

For gene therapies, some elements of manufacture, including purification, can be scaled up using traditional processes. However, challenges associated with transient transfection at large volumes remain. Until technology exists to enable the growth of cells to a high cell density so that gene therapies can be produced in higher amounts, the cost of goods will continue to be a barrier.

Difficulties associated with collection of patient materials and delivery of therapeutic product to the patient all present major challenges due to their unique nature. On top of this, CMC analytical strategies need to be set in place to ensure stability and minimise variability from early development to manufacture. Sample numbers can be orders of magnitude greater than in traditional bioprocess.

These challenges can only be addressed by advanced engineering solutions and innovative biotechnologies, which consider the complexity of the biology and reduce the difficulty and labour- intensive steps that currently exist. This will enable the production of therapeutic doses at a cost that will make these treatments accessible for a larger number of patients.

Explore More industries

Life Science

We work at the intersection of physics, engineering and the biological sciences, creating and developing new technology for the life science industry.

Drug Delivery

Pharmaceutical companies face substantial challenges, from constraints in health spending to weakening drug pipelines. Yet opportunities exist for those bold enough to adapt, ranging from connected devices that drive adherence to generic devices at cost points previously thought impossible.

Medical Devices

Disruptive change is rolling through the medical device industry as value-based healthcare and digitisation spread from niches to the mainstream. This is a challenging time, but it presents real opportunities for those ambitious companies prepared to reinvent themselves.

In-vitro Diagnostics

The diagnostic market is at a moment of change. New approaches, such as sequencing, are gaining traction; companion diagnostics are driving closer integration with therapy; continuous monitoring is enabling new diagnostic information; and market drivers are demanding low cost distribution of clinical quality data.

Bioprocess

Human therapies are adapting to tackle increasingly complex immunological diseases and conditions. These therapies often rely on tightly controlled cell cultures in order to produce therapeutic drugs efficiently, such as monoclonal antibodies or culture of the patient’s own genetically-engineered cells, as part of an autologous cell therapy workflow.

Biosensors

Emerging biosensor technologies are enabling the measurement and analysis of valuable trace markers, leading to improved clinical outcomes by allowing the accurate observation of previously undetectable physiological signals in real time.

Smart Implants

Increasing numbers of people are suffering from chronic conditions. Through the creation of tiny, fully integrated real-time measurement systems, smart implants are bringing the benefits of laboratory-grade telemetry to their lives.

Digital Health

As with other industries, digital technology is touching every aspect of healthcare. But health is unique in its complexity, and innovation requires deep insight.

Medical Imaging

Medical imaging is required to meet the needs of advanced diagnostics and the demands of emerging markets, presenting the sector with sizeable rewards for innovation.

Surgical

Surgery is a fertile area for medical device innovation with remarkable developments occurring in minimally invasive and robotic assisted techniques. The future of the operating room relies on intraoperative technologies which improve clinical and economic values as measured by procedure outcome, workflow efficiency and patient safety.

Neurotechnology

Neurotechnology promises to revolutionise the treatment of a wide range of diseases. Improving outcomes for patients depends on bringing together an understanding of the pathology with the medical device hardware needed to physically interface with the nervous system.

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