Case studies

Puckdx™ – TTP’s robot in a coffee pod

Puckdx™ is one of TTP’s uniquely flexible and low cost solutions for translating sample-to-answer diagnostic assays to a simple, easy-to-use desktop device.

  • Industries
    Life Science, In-vitro Diagnostics
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Context

Over and above demands for accuracy, ease of use and reliability, TTP noticed recent common needs in the near-patient diagnostics market: the ability to cope with an expanding menu of assays, small footprint, and above all low-cost.

Solution

By combining TTP’s knowledge in fluid manipulation, medical devices and high-volume consumer products, Puckdx™ became a flexible and low-cost platform for the automation of sample-to-answer diagnostic assays.

Result

Puckdx™ enables companies to enter the diagnostic market with the potential to be market leader in terms of cost, speed and flexibility. The simplicity of the design means that the system can be tailored to different chemistries and assays.

Puckdx™: TTP's platform for the automation of sample-to-answer diagnostic assays

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Laboratory scientists typically use handheld or robotic pipettes to dispense, mix and elute samples. Most diagnostic systems perform similar fluid movements to prepare samples for diagnosis.

With this in mind, we developed a unique disposable robotic pipette system capable of performing almost any desired series of steps in the same way as they would be carried out at the lab bench.

Proof-of-principle test rigs allowed us to validate the design approach and specify the different modules of the system. For example, thanks to our know-how in thermal design, our current PCR module is capable of completing 30 cycles in 7 mins.

In 2018, we built an Alpha prototype that can extract and amplify DNA/RNA from a sample in <15 mins.

The modular platform can be customized for molecular and immunoassay tests as well as single-use automation and integration of other diagnostic assays in its low-cost, single-use, disposable cartridge.

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Puckdx - your biology. enabled.

The Puckdx™ cartridge has been designed for simplicity in use and manufacture: it contains all the reagents and is inherently robust as it only has one moving part and few critical dimensions, guaranteeing high manufacturing yields and market-leading low cost.

The Puckdx™ system offers a fully flexible solution for translating complex tests to a simple device that requires no operator expertise and is capable of providing fast or ultra-fast assay results. A customized system ready for clinical testing can be produced in 12–15 months.

We are now looking to combine Puckdx™ with LEX, TTP’s ultra-efficient thermal control technology, to obtain a complete solution for ultra-fast point-of-care diagnostics. This will potentially provide sample to answer molecular assays with 2 minute post-prep PCR time.

Quote

The approach to liquid handling in the disposable is key to enabling easy translation from a lab-based protocol to product, thus providing fast-track and low-cost assay/protocol expansion.

Piers Harding

Inventor of the Puckdx™ technology at TTP plc

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  • Client
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